ZEB1 and Familial prostate cancer: Several target genes of miR-200a have been validated; these genes are associated with the immune signaling pathway including E-cadherin repressors, the wnt/β-catenin signaling pathway in gastric adenocarcinoma, ZEB1/ZEB2 [36] and suppression of castration-resistant prostate cancer by inhibiting the activation of BRD4-mediated AR signaling in humans [37].