PAQR8 and disease arising from reactivation of latent virus: Deleterious SNPs defining of AA1SA strains include variants in genes with roles in transport of drugs across the membrane (Rv1877) [49], macrotetrolide resistance (Rv2303c; based on cross-species protein similarity) [50], pathogenesis and reactivation from latent infection (two-component sensor kinase, mprB) [51] and the entry of hydrophilic molecules into the bacterial cell (ompA) [52].