HIF1A and chronic myelogenous leukemia, BCR-ABL1 positive: Importin 7 (IPO7) is a mediator specifically related to HIF-1α nuclear translocation [161], while in chronic myelogenous leukemia cells under curcumin treatment, there is a curcumin-induced downregulation of IPO7 expression caused by miR-22 activation, which further elicits blocked cytoplasm-to-nucleus shuttling of HIF-1α to restrain the glycolytic enzyme profile [153].