The Ras Homolog C/Rho-Associated Coiled-Protein Kinase (RHO/ROCK) pathway plays an important role in mediating various cellular functions, including contraction, actin cytoskeleton, cell adhesion and movement, proliferation, cytokinesis, and gene expression, all of which are involved in the pathogenesis of cardiovascular disease [26, 27]. The gene discussed is RHO; the disease is cardiovascular disorder.