The sensitivity versus specificity of IL-36α, IL-36β and IL-36γ production were determined using ROC curve analysis [28] and were found to be predictive of the presence of cancer, yielding AUC values of 0.68, 0.73 and 0.65 for IL-36α, IL-36β or IL-36γ, respectively. The gene discussed is IL36B; the disease is cancer.