IL36A and metastatic malignant neoplasm in the lymph nodes: IL-36α (HR, 0.31; 95%CI, 0.13–0.69; P = 0.004), IL-36γ (HR, 2.33; 95%CI, 1.05–5.16; P = 0.04), lymph node metastasis (HR, 2.87; 95%CI, 1.31–6.28; P = 0.008), tumour invasion depth (HR, 3.30; 95%CI, 1.38–7.87; P = 0.007) and TNM (HR, 2.47; 95%CI, 1.46–4.18; P = 0.001) were found to be good predictors for prognosis in univariate analyses for survival of patients with CRC.