Concomitant use of dabigatran with P-gp inducers such as rifampin reduces the anticoagulant effect of dabigatran and should be avoided whereas use of dabigatran with P-gp inhibitors (eg, ketoconazole, dronedarone) in patients with renal disease may increase the anticoagulant effect, hence dose adjustment is required. Here, PGP is linked to kidney disorder.