In contrast, whereas NSE intracranially locates primarily to neurons,9 extracerebral NSE emanates from, among other sources, erythrocytes.9,77 Hence, extracerebral NSE is a confounding factor following both multi-trauma and hemolysis.9 Importantly, there is no clear period after trauma when this is important, but rather this potential confounder spans the entire data material and contributes a latent data noise. This evidence concerns the gene ENO2 and hemolysis.