While the α particle radiotherapy study showed specific and potent tumor control derived from [225Ac]αMSH-PEG-Cy5-C′ dots (Fig. 4B, C), an additional therapy study was included to investigate tumor control arising from a single administration of 55 pmol of unlabeled cold αMSH-PEG-Cy5-C′ dots on day 8 versus vehicle-treated controls (Supplementary Fig. S4). This evidence concerns the gene STAMBP and neoplasm.