Pharmacodynamic studies examined B16-F10 tumor control, host survival, and associated effects on the TME immune cell content using an immunocompetent mouse model of melanoma following a single IV administration of 11.1 kBq (300 nCi) of [225Ac]αMSH-PEG-Cy5-C′ dots. This evidence concerns the gene STAMBP and neoplasm.