While it is evident that both labeled and unlabeled αMSH-PEG-Cy5-C′ dots prompt changes in CD8 T and Treg cells, monocytes, MΦ and M1 macrophages, and activated NK cells, the cytotoxic 225Ac component of the drug is necessary to introduce a potently cytotoxic element and effect tumor control. The gene discussed is CD8A; the disease is neoplasm.