In this case, silybin, the major pharmacologically active compound of the S. marianum fruit, has also showed the ability to protect against cisplatin-induced acute kidney injury and tubular cell apoptosis both in vitro (HK2 cells) and in vivo (SIRT3 knockout mice) by improving mitochondrial function through the elevation of SIRT3 expression [54]. Here, SIRT3 is linked to acute kidney injury.