However, despite the low number of neoantigens, UM expresses a couple of immunogenic antigens as melanoma antigen recognized by T cells (MART-1/Melan-A), glycoprotein 100 (gp100), tyrosinase, tyrosinase-related protein-1 (TRP-1) [175], or melanoma-associated antigen (MAGE) [176]. The gene discussed is TYRP1; the disease is melanoma.