AKT1 and neoplasm: Notably, down-regulation of miR-20b and up-regulation of miR-451a expression exhibits an anti-tumor effect in vitro (reduced viability, colony formation, increased apoptosis rate and reduced colony forming ability, miR-20b, and miR-451a respectively) by targeting genes involved in PI3K/AKT/mTOR tumorigenesis signaling pathway.