PTEN and gastric cancer: Using in silico analysis, we selected potential target genes of miR-20b: IRF, PTEN, and TXNIP and miR-451a: CAV1 and TSC1. These genes are involved in phosphatidylinositol-3-kinase (PI3K)/AKT/mTOR signaling pathway which has potential prognostic and predictive significance in GC [36,37].