However, we have recently shown that in neuroblastoma cells, TrkA does not belong to lipid rafts where GM1 is located, but its interaction with GM1 and the following stabilization which leads to its autophosphorylation involves only the GM1 oligosaccharide chain and the extracellular portion of TrkA, that may flop down on the plasma membrane approaching the GM1 oligosaccharide chain [96]. This evidence concerns the gene NTRK1 and neuroblastoma.