It should be noted that the majority of cardiomyopathies causing de novo mutations have been reported in syndromic cases such as those caused by variants in DSP (Naxos–Carvajal syndrome [3], erythrokeratodermia-cardiomyopathy syndrome [4]), LAMP2 (Danon disease [5]), PRKAG2 (glycogen storage disease of heart [6,7]), RAF1 (Noonan syndrome [8]), TAZ (Bart syndrome [9]), RRAGC (syndromic fetal dilated cardiomyopathy [10]), and LMNA (atypical progeroid syndrome and dilated cardiomyopathy [11]). This evidence concerns the gene DSP and cardiomyopathy.