In another two cases of sporadic DCM, we found de novo mutations in potential novel DCM candidate genes, TRIB3 and SLC2A6. In the remaining two probands, there was a possible disease-causing biallelic genotype (APOBEC genes), and a de novo mosaic variant in the UNC45A gene without strong evidence of pathogenicity was found. Here, TRIB3 is linked to familial dilated cardiomyopathy.