In the present study, the significant positive associations of GPx1 to known cardiometabolic factors such as age, BMI and blood pressure, as well as the inverse association with LDL-cholesterol, highlight the known protective role of GPx1 in decreasing the chronic sub-inflammatory status observed in diseases such as T2DM [31,32,33]. This evidence concerns the gene GPX1 and type 2 diabetes mellitus.