Finally, overexpression of isoforms of HDAC (HDAC1, HDAC2, HDAC3, HDAC4, and HDAC5) and in particular HDAC6 was more frequently observed in LSCs (CD34+ CD38-) isolated from patients with CML than in K562 cells [117] (Figure 6B), making it a protein of interest in the search for treatments to prevent relapse in patients with CML. This evidence concerns the gene HDAC4 and chronic myelogenous leukemia, BCR-ABL1 positive.