In lung cancer cells, the interaction between PHF20 and H3K4me2 was disrupted by mutating PHD finger of PHF20, it further reduced MOF mediated H4K16ac targeting gene activation, as well as the preference of PHF20-Tudor2 for p53 dimethylation, suggesting the involvement of PHD finger in anti-cancer processes [99]. Here, PHF20 is linked to lung carcinoma.