Even more interestingly, not only the density of SOD1 amorphous aggregates was significantly higher in locus coeruleus and substantia nigra of PD brains in comparison to age-matched controls, but it was also significantly more elevated than all nondegenerating regions of the same PD brains, suggesting an association between SOD1 aggregation and neuronal degeneration [77]. The gene discussed is SOD1; the disease is Parkinson disease.