Using macrophages from mice with deletion of the TRPM7-kinase domain it was revealed that such cells are able to induce a fibrotic phenotype (i.e., increased TGF-β) in CFs from WT mice and interestingly this effect was prevented by MgCl2 treatment [103]. The gene discussed is TGFB1; the disease is myalgic encephalomeyelitis/chronic fatigue syndrome.