In multivariate (per-patient) analysis, multinodular HCC (HR = 2.67, p < 0.001), treatment-naïve patient (HR = 0.507, p = 0.002) and AFP > 100 ng/mL (OR = 2.767; p = 0.014) independently predicted time-to-IDR (confirmed after internal validation by bootstrapping, data not shown) (Figure 3). Here, AFP is linked to hepatocellular carcinoma.