To underline the importance of these three key glycolytic biomarkers inhibited by OLEO: (1) GLUT1 is the major glucose transporter in cancer cells; (2) PKM2 is a modulator of glucose metabolism sustaining building block generation needed for cell proliferation; (3) MCT4 exports lactate and protons produced by glycolysis, preventing the inhibition of glycolytic enzymes such as phosphofructokinase activity, that is reduced by intracellular acidification. The gene discussed is PKM; the disease is cancer.