Human GBM T98G cells containing relatively low levels of GLUD2 presented higher proliferation and the ability to form colonies compared to the other human GBM cell line, U118, expressing considerable amounts of GLUD2. Overexpression of GLUD2 in T98G cells decreased proliferation and motility while the silencing of this gene in U118 cells increased these parameters. This evidence concerns the gene GLUD2 and glioblastoma.