Another study showed that oral intake of AITC-rich mustard seed powder inhibits tumor growth and muscle invasion in an orthotopic rat BC model via regulation of apoptosis, cell cycle, and angiogenic potential [52]; downregulation of vascular endothelial growth factor and cyclin B1 and upregulation of caspase-3 and cleavage of PARP were found associated with these anti-cancer effects [52]. This evidence concerns the gene CASP3 and cancer.