CASP3 and cancer: Moreover, induction and stimulation of cyclin B1 and Cdk1 were found associated with the anti-proliferative effects of SFN, whereas activation of caspase-3, 8, and 9 and PARP corresponded to its pro-apoptotic effects; these SFN-induced anti-cancer effects are speculated to be regulated via reactive oxygen species (ROS)-dependent mechanisms [91].