TNFSF10 and breast cancer: SFN treatment however, has been reported to reverse the pro-apoptotic activity of TRAIL in TRAIL-resistant BC cells [103]; the SFN-induced mechanisms were found associated with apoptosis-related molecules (e.g., caspases, mitochondrial membrane potential, Bid, and death receptor 5) and oxidative stress-related factors (e.g., ROS and Nrf2).