INS and Hand-foot syndrome: Quantification of plasma glucose and insulin at the end of the 25-week protocol (Figure 2E, Table 1) confirmed the fasting hyperglycemia and increased plasma insulin concentrations in both HFS and HFS + D groups compared with those in the NC group (Figure 2E) and HOMA-IR increased, in both HFS and HFS + D groups compared with that in the NC group (Figure 2F).