Indeed, in gastric and breast cancer cells it was found that RXRα is able to form a heterodimer with the orphan receptor TR3 (also known as NGFI-B and nur77) in the nucleus, and when the ligand 9-cis RA link to RXRα, all the heterodimer 9-cis RA/RXRα/TR3 co-translocated in the cytoplasm and then localized in the mitochondria [123]. This evidence concerns the gene NR4A1 and breast carcinoma.