Conversely, an over-expression of RARα was found in 32 resected samples of HCC in comparison to 14 samples of normal liver tissue, and in vitro experiments showed that when RARα is overexpressed, HCC cell lines are growth inhibited by retinoids’ concentrations that not altered the growth of primary-cultured hepatocytes [146]. The gene discussed is RARA; the disease is hepatocellular carcinoma.