A dominant model of AD, the amyloid cascade hypothesis, holds that an abnormal accumulation of Aβ plaques in the interneurons of the brain triggers a cascade of events: microglia and astrocytes activation, chronic inflammation, increased glutamate levels, elevated intracellular calcium, oxidative stress, synaptic dysfunction, tangle formation by tau hyperphosphorylation, neuronal loss, and finally dementia [18]. Here, MAPT is linked to Alzheimer disease.