One such disease is AD, where it has been reported that there is a “metal-swap” event with zinc-bound MT-3 (Zn7MT-3) such that MT-3 removes copper from aggregated and soluble β-amyloid-copper complexes (in turn exchanging metal species within MT-3, going from Zn7MT-3 to Cu4Zn4MT-3; β-amyloid is considered a primary toxic moiety in AD, and is the primary constituent of the β-amyloid plaque that characterizes the AD brain) to then prevent ROS production and subsequent cellular toxicity [23]. This evidence concerns the gene MT3 and Alzheimer disease.