However, all the tests retained their statistical significance for prediction of OS in multivariate analyses that included various prognostic factors and available biomarker measurements: the BDX008 test was an independent predictive factor (p = 0.009) when adjusted for BRAF mutation status, line of treatment, and LDH in an independent validation cohort of melanoma patients [46]; the ICB classification remained a significant predictor of survival (p = 0.002) when adjusted for gender, age, LDH, PD-L1 expression, prior treatment, and tumor size [43]. This evidence concerns the gene CD274 and melanoma.