TGF-β release by PC cells in turn inhibits the transcription of CTL cytotoxic genes: perforin, granzyme A, granzyme B, Fas ligand, and IFN-γ, in vitro; these data support the hypothesis that TGF-β targeting could restore cytotoxic response involved in in vivo tumor clearance [143]. Here, TGFB1 is linked to neoplasm.