Cytokines are a family of soluble factors, classified into growth factors, chemokines, angiogenic factors and interferons and involved in tumor immune-landscape, by exerting pro- (IL-1β, IL-6, IL-8, and macrophage migration inhibitory factor—MIF) and anti-inflammatory (IL-10 and TGF-β) functions [184]. This evidence concerns the gene IL1B and neoplasm.