PC desmoplastic stroma is a complex environment composed by both cellular and acellular components, such as cancer associated fibroblasts (CAF), immune cells (macrophages, neutrophils, myeloid-derived suppressor cells (MDSC), lymphocytes), and endothelial cells, on one hand, and collagen, fibronectin, and soluble factors (cytokines and chemokines), on the other (Figure 1). This evidence concerns the gene FN1 and cancer.