TME, on the other hand, may activate tumor cell signaling pathways which, in turn, cause profound TME remodeling: for example, FAK by PC cell’s integrin binding to fibronectin and collagens induces fibrosis and poor CD8+ cytotoxic T cell infiltration; inhibition of intracellular FAK signaling reduces tumor fibrosis, decreases the numbers of tumor-infiltrating immunosuppressive cells, and restores PC sensitivity T cell immunotherapy and PD-1 antagonists [183]. This evidence concerns the gene CD8A and neoplasm.