Among many examples, inhibitors of the methyltransferase EHMT2 were shown to induce apoptosis of BlCa cells [42,43,44]; natural compounds such as Honokiol (derived from Magnolia officinalis) inhibited BlCa growth by suppressing EZH2/miR143 [45]; and various histone deacetylase (HDAC) inhibitors were shown to be effective in reducing BlCa growth [46,47,48,49], showing synergy with other classically used therapies such as mitomycin C [50] and additionally increasing sensitivity to chemo- [51] and radiotherapy [52,53]. This evidence concerns the gene EZH2 and bladder transitional cell carcinoma.