LDHA and cancer: Despite what we reported about the decreased glycolysis in uPAR KO cancer cells detected via the Seahorse platform, we observed that they release a higher amount, compared to control cells, of lactate—the very final product, together with protons, of the glycolytic pathway—in the extracellular media, as shown in Figure 4B. To explain such a discrepancy, we evaluated the expression levels of Lactate Dehydrogenase A and B (LDHA and LDHB), which are responsible for the conversion of pyruvate to lactate and vice versa, respectively.