They propose that the mechanism of action is associated with a decrease in mitochondrial membrane potential and the release of cytochrome c, and that it may be amplified by inhibition of extracellular signal-regulated kinases (ERKs) 1/2 signaling; they also suggest it may be caused by a mechanism dependent on intracellular ROS generation in leukemia cells [19]. This evidence concerns the gene CYCS and leukemia.