Decreased cell migration and proliferation following treatment of HCC cells with different compounds was accompanied by upregulation of OCLN expression, indicating mesenchymal-epithelial transition (MET) [139,140,141] and thus supporting the findings from Bouchagier et al. Expression of tricellulin is very heterogeneous in HCC tissues, but seems to be positively correlated with poor prognosis [101]. Here, MARVELD2 is linked to hepatocellular carcinoma.