The RT-PCR analysis showed poststroke declines in the mRNA expression of PPARγ-targeted downstream genes CD36 and FABP4 and endothelial junction proteins in cerebral microvascular fragments of db/db mice were largely prevented by rFGF21 administration, suggesting that rFGF21 targets specific pathological responses in cerebral microvasculature after T2DM stroke. This evidence concerns the gene PPARG and stroke disorder.