PPARG and ischemic stroke: Although, as a transcriptional factor, how the rFGF21-activated PPARγ regulates subesequent signaling pathways in modulating junction protein expression and preserving BBB integrity remains to be elucidated, accumulating experimental evidence has supported the critical roles of PPARγ activity in not only BBB protection, but also improvement of cellular survival and recovery of homeostatic equilibrium after ischemic stroke [12].