IL1B and Hyperglycemia: Subsequently, cultured HBMEC monolayer permeability after the injury by hyperglycemia plus IL-1β was measured (Figure 4B), and, as we expected, cell permeability was dramatically increased after injury (75.7% elevation compared to that in the noninjured group) while the rFGF21 treatment significantly reduced cell permeability by 28.9% compared to that in the nontreated group.