Regarding venous stasis ulcers, immunofluorescent studies provide mixed evidence: some authors reported intense TGF-β1 expression in the epidermis next to the ulcer edge, along with reduced TGF-β3 and negligible TGF-β2 staining [81], in contrast with other authors, who reported moderate TGF-β2 and 3 levels with negligible TGF-β1 expression in biopsies that included epidermis next to the wound bed [82]. This evidence concerns the gene TGFB1 and varicose ulcer.