In line with these results from Lorenzo et al., Fizelova et al. also found a positive association between GlycA and impaired insulin secretion in a population of 5401 non-diabetic men from the prospective Metabolic Syndrome in Men study (METSIM), in addition to the above-mentioned results by other authors with hyperglycemia, incident T2DM, and CVD [102]. This evidence concerns the gene INS and type 2 diabetes mellitus.