In sarcomas, ALT has been linked to chromosomal instability in osteosarcomas and chondrosarcomas [77] and to complex karyotypes in soft tissue sarcomas [78,79], with the observation that sarcomas harboring specific translocations were more likely to display a telomere length similar to that of normal, adjacent tissue and have near-normal karyotypes, as opposed to the heterogeneous telomere length and complex karyotypes seen in ALT positive sarcomas. The gene discussed is GPT; the disease is sarcoma.