Although MHO subjects present preserved high insulin sensitivity, a favorable lipid profile (e.g., reduced levels of triglycerides), increased levels of adiponectin and/or absence of hypertension and, so, a reduced risk of developing T2DM and CVD, there is no evidence protection is permanent [5,35,36,37,42,48,49]. The gene discussed is INS; the disease is type 2 diabetes mellitus.