Consistently, McLaughlin et al. reported that an expanded population of subcutaneous small adipose cells together with lower expression of preadipocyte differentiation markers (e.g., peroxisome proliferator-activated receptor γ (PPARγ) 1 and 2, glucose transporter type 4 (GLUT4), adiponectin) are linked to insulin resistance, thus suggesting impaired cell differentiation in this tissue may contribute to obesity-associated insulin resistance [74]. Here, ADIPOQ is linked to Insulin resistance.