Additionally, Meigs et al. reported that insulin-sensitive obese individuals present a three-times higher risk of T2DM (after 11 years of follow up of 2902 men and women) when compared to insulin-sensitive normal-weight subjects, pointing towards the diabetogenic nature of obesity even in the initial absence of insulin resistance [35]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.