Breast cancer cells direct the tumor angiogenesis via pro-angiogenic factors such as interleukin-1 (IL-1), interleukin-8 (IL-8), vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), tumor necrosis factor α (TNFα) and matrix metalloproteinases 9 (MMP9) [5]. The gene discussed is TNF; the disease is breast cancer.