During viral infection, NLRX1 was also demonstrated to negatively regulate RIG-I activation through interaction with poly(rC) binding protein 2 (PCBP2) and mitochondrial anti-viral signaling (MAVS) via its NACHT domain to cause lysine 48 (K48)-linked polyubiquitination and degradation of MAVS [92]. Here, PCBP2 is linked to viral infectious disease.