TNF and Reoviridae infectious disease: DDX1, DDX21, and DHX36 knockdown caused a 60–70% reduction in IFN-β production and a 40–50% reduction in TNF-α production by D2SC cells upon influenza A virus, whereas a 70–80% reduction in IFN-β production and a 60–70% reduction in TNF-α production was observed in D2SC cells upon reovirus infection [149].