TIMP1 and neoplasm: In addition, to better characterize the molecular pathways mediating the role of TIMP1 on cell dissemination, we analyzed the gene expression levels of cell plasticity markers (E-cadherin, N-cadherin, CD133 and Vimentin) after TIMP1 down-regulation, finding a reduction of N-cadherin and CD133 and an increment of E-cadherin levels in both the tumor cell lines and the tumors generated in the mice model (Figure S4B and Figure 5C).