Physiologically, CKD5 can inhibit GSK3β indirectly via the LMTK2-mediated signaling pathway [29,30,31], whereas in AD, caspase overactivation leads to cleavage of cofactor p35 into p25 and p10 [32,33,34,35,36,37]. The gene discussed is LMTK2; the disease is Alzheimer disease.