The importance of T-cell–mediated TLR signaling is emphasized by reversed or delayed tumor growth of B16 melanoma in tumor-bearing MyD88 knockout mice that received adoptive transfer of TCR-transgenic CD8+ pmel T cells, after peritumoral injections of Pam3CSK4 (a synthetic TLR2 agonist) [157]. This evidence concerns the gene CD8A and melanoma.