The evidence for PD-related monogenic mutations, having a role in astrocyte biology, has been mostly found in relation to α-Synuclein (PARK1) parkin (PARK2), DJ-1 protein (PARK7) [5,32,66,68], and PINK1 [5,68,73] gene expressions (Table 1). This evidence concerns the gene PRKN and Parkinson disease.