PRKN and Parkinson disease: As mentioned in Table 1 below, the mutations of these genes are involved in the development of autosomal recessive PD pathogenic pattern, namely PARK1 (α-Synuclein), PARK2 (Parkin), PARK6 (PINK1 or PTEN-induced putative kinase-1), PARK7 (DJ-1), PARK8 (LRRK2 or Leucine-rich repeat kinase 2) [5,32,66], PARK8 (LRRK2) [5,32,33], NR4A2 (NURR1) [67], FBX07 (PARK15, F-box only protein 7], and vacuolar protein sorting (VPS35) [66,68].