In the OPL (Figure 6) and in the ILC (Figure 7) of 3xTg-AD eyes, the cell body area of Iba-1+ cells was significantly thicker compared to the control eyes, both for the mean of all retinal areas and by quadrant (superior, inferior, nasal, and temporal) (p < 0.001 in all instances). The gene discussed is AIF1; the disease is Alzheimer disease.