TNF and cancer: Studies on the anti-neoplastic effects of FaOH and FaDOH in tumors of cancer-primed rats for CRC have demonstrated that these polyacetylenic oxylipins inhibit pro-inflammatory and transcription factor biomarkers for inflammation and cancer such as COX-2, interleukin 6 (IL-6), tumor necrosis factor alfa (TNF-α) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) [21].