CD274 and cancer: ATF7IP/MCAF1 functions for either DNA methylation‐based gene repression or the transcription factor Sp1‐mediated gene activation.36 On the other hand, PD‐L1 is generally produced by cancer cells to escape immune surveillance, and is a molecular target for cancer immune therapy.41, 42, 43 Previous report showed that the PD‐L1gene promoter is regulated by DNA methylation or Sp1 binding in cancer cells.44, 45 There is the possibility that ATF7IP/MCAF1 may control PD‐L1 expression via Sp1,as indicated by published ChIP‐seq data of colon cancer (Figure S3A).