Since MIF was shown to be a key player in trypanosomosis-associated pathogenicity and found to be strongly induced in hepatocytes from TgAlbCre-IL10-/- mice compared to the other groups, and interfering with MIF signaling using a Nb-based approach attenuates the excessive inflammatory immune response as well as the most prominent pathological feature associated with T. congolense infections, i. e. anemia, in TgAlbCre-IL10-/- mice, this could be a prime candidate for further studies in this model. Here, IL10 is linked to anemia.