Although early peak parasitemia was similar in all mouse strains, TgAlbCre-IL10-/- mice exhibited significantly higher parasitemia levels during the later stage of infection as well as an increased weight gain (due to increased spleen and liver weight), more severe anemia and a significantly reduced median survival time (Fig 2A–2D, median survival time WT: 102 ± 26; LysM-IL-10-/-: 100 ± 14, TgAlbCre-IL10-/: 50 ± 10 days). Here, IL10 is linked to parasitic infectious disease.