Regarding the Ly6Chigh monocytes, which play a key role in pathogenicity development, we observed a similar increase in all groups as the infection progresses, whereby these cells already exhibited a significant upregulation of MHC-II at day 7 p.i. Interestingly, at the later stages of infection their MHC-II expression was significantly higher in TgAlbCre-IL10-/- mice compared to WT and LysM-IL-10-/- mice (Fig 4C), indicative of a higher monocyte activation level. Here, IL10 is linked to infection.