In addition, at later stages of infection, the numbers of PMN as well as the expression of MHC-II on Ly6C+ inflammatory monocytes, both documented to contribute to tissue injury [22,26], were found to be significantly increased in the blood of TgAlbCre-IL10-/- mice compared to the other groups, further strengthening the notion that these mice were in a higher inflammatory state. The gene discussed is IL10; the disease is infection.