CYP2R1 and colorectal cancer: Heterozygote carriage of CYP2R1/rs10741657 and GC/rs4588, and carriage of two risk alleles (estimated by a genetic risk score) were weakly associated with 9–12% decreased risk of colorectal cancer per 3 μg intake of vitamin D per day (IRRCYP2R1/rs10741657 = 0.88, 95% CI: 0.79–0.97; IRRGC/rs4588 = 0.91, 95% CI: 0.82–1.01, IRRGRS2 = 0.90, 95% CI: 0.81–0.99).