SMAD4 and systemic lupus erythematosus: In the third trimester, systemic lupus erythematosus and proteasome were enriched in the acute disease while Fc gamma R-mediated phagocytosis (VAV1, MARCKSL1, WASF2, DNM2, HCK, MAP2K1 genes) and adherens junction (ACTG1, WASF2, SMAD4, CSNK2B, EP300 genes) represented the subclinical category (Fig 9B).