In the third trimester, systemic lupus erythematosus and proteasome were enriched in the acute disease while Fc gamma R-mediated phagocytosis (VAV1, MARCKSL1, WASF2, DNM2, HCK, MAP2K1 genes) and adherens junction (ACTG1, WASF2, SMAD4, CSNK2B, EP300 genes) represented the subclinical category (Fig 9B). This evidence concerns the gene MAP2K1 and systemic lupus erythematosus.