E2F3 and ovarian carcinoma: In agreement, Giannakakis et al. (2008) demonstrated that induction of miR-210 down-regulates E2F3, an important transcription factor involved in the regulation of the cell cycle in ovarian cancer cells.[43] In addition, melatonin negatively alters c-Myc expression and impairs migration on cells showing reduced levels of miR-210.